UNO (the University of New Orleans) Press publishes fiction, nonfiction, and academic work that focuses on, but is not limited to, the southeastern region of the United States.
It is easy to get a feel for what they publish by visiting their store. I do not know who their distributor is, but most university presses have at least good regional distribution.
They publish primarily nonfiction work of the academic and non-academic variety. Though the literary fiction they publish seems compelling, at least based on their website, they really publish very little fiction, a book every couple years. This means that they are much more likely to accept nonfiction submissions.
Their covers are a bit of a mixed bag. I like the covers of their nonfiction better than their fiction and poetry covers (they are not open to poetry submissions currently).
To submit to them a proposal containing a one-page description of the work, a table of contents, and biographical information about the author. Do not send full manuscript unless requested.
They accept online submissions via email as well as postal submissions. It takes them between six and eight months to respond to submissions. Do not query before eight months has passed. They do not say anything about accepting or not accepting simultaneous submissions.
To learn more or to submit go here.
Emily Harstone is the pen name of an author whose work has been published internationally by a number of respected journals. She is a professional submissions adviser and spends much of her time researching manuscript publishers. You can follow her on Facebook here.