Updated February 2024: Due to ongoing health issues they are closed to submissions for the foreseeable future.
Small Beer Press has now been around for over a decade and published some rather well known authors including Ursula K. Le Guin. They publish literary work leaning towards the speculative.
Although, to really know what they publish I highly recommend checking out one of their books from the library as well as browsing their catalog. What they are looking for is rather specific. They only publish between 6-10 books a year. They are not interested in poetry manuscripts or chapbook length work.
Their website is well designed and focused on books. Their blog seems to be very regularly updated, which is a good sign. Their links to imprints are no longer working, but that was the only major error I could find on the organized and well maintained website.
They only accept submissions via the mail. Do not email editors directly with a query. Instead send a query letter and the first 10-20 pages of the manuscript to them, via the post, along with a self addressed and stamped envelope (SASE).
This press also publishes a literary zine (Lady Churchill’s Rosebud Wristlet), which you might consider submitting to as well. The submission guidelines are on the same page. Submissions to the literary journal are also made through the post.
To learn more visit their submission guidelines here.